Catálogo de publicaciones - revistas

<jats:title>Targeting parasite's protein kinase</jats:title> <jats:p> Malaria elimination goals are constantly eroded by the challenge of emerging drug and insecticide resistance. Alam <jats:italic>et al.</jats:italic> have taken established drug targets—CLK protein kinases involved in regulation of RNA splicing—and investigated how inhibition of the parasite's enzymes blocks completion of its complex life cycle. They identified an inhibitor of the parasite's CLK protein kinase that was 100-fold less active against the most closely related human protein kinase and effective at clearing rodent malaria parasites. Not only does this compound halt the development of sexual stages but it also limits transmission to the mosquito vector of the parasite, a key requirement for malaria drugs. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aau1682">eaau1682</jats:related-article> </jats:p>

<jats:title>Neurons negotiating boundaries</jats:title> <jats:p>Barriers around the brain and spinal cord separate central from peripheral nervous systems, yet the two systems are interlinked. Suter and Jaworski review what is known about how cells, axons, and signals negotiate the boundary zone. Understanding what goes wrong in boundary transgressions reveals the inner workings of multiple, partially redundant mechanisms built during development that separate the two compartments in adulthood.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaw8231">eaaw8231</jats:related-article> </jats:p>