Catálogo de publicaciones - revistas

<jats:title>The genetics of sexual orientation</jats:title> <jats:p> Twin studies and other analyses of inheritance of sexual orientation in humans has indicated that same-sex sexual behavior has a genetic component. Previous searches for the specific genes involved have been underpowered and thus unable to detect genetic signals. Ganna <jats:italic>et al.</jats:italic> perform a genome-wide association study on 493,001 participants from the United States, the United Kingdom, and Sweden to study genes associated with sexual orientation (see the Perspective by Mills). They find multiple loci implicated in same-sex sexual behavior indicating that, like other behavioral traits, nonheterosexual behavior is polygenic. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aat7693">eaat7693</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6456" page="869" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aay2726">869</jats:related-article> </jats:p>

<jats:title>Thirteen is the charm in anaphylaxis</jats:title> <jats:p> Immunoglobulin E (IgE) is a type of antibody associated with allergies and response to parasites such as worms. When high-affinity, allergen-specific IgE binds its target, it can cross-link receptors on mast cells that induce anaphylaxis. It remains unclear, however, how B cells are instructed to generate high-affinity IgE. Gowthaman <jats:italic>et al.</jats:italic> discovered a subset of T follicular helper cells (T <jats:sub>FH</jats:sub> 13) that direct B cells to do just that. T <jats:sub>FH</jats:sub> 13 cells are induced by allergens but not during parasite infection. Transgenic mice lacking these cells show impaired production of high-affinity, anaphylactic IgE. T <jats:sub>FH</jats:sub> 13 cells, which are elevated in patients with food and aeroallergies, may be targeted in future antianaphylaxis therapies. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaw6433">eaaw6433</jats:related-article> </jats:p>

<jats:p>These are dark times for science and public policy in the United States. In June, it was revealed that the White House suppressed the congressional testimony of a State Department scientist on the implications of climate change for national security—just the latest example of evidence undercut by ideology. Yet, despite this gloomy backdrop, there are glimmers of scientific evidence used to improve policy and practice. In July, a bipartisan group formed the Congressional What Works Caucus to encourage federal investments in evidence-based programs and policies. Since January, the Foundations for Evidence-Based Policymaking Act has pushed federal agencies to develop learning agendas and appoint chief data officers to make better use of government data. What will it take to keep the light of evidence burning and ensure that the best science informs important decisions of our time?</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p> A <jats:italic>Lancet</jats:italic> panel wants to end the disease by 2050. A WHO panel says that's not realistic. </jats:p>

<jats:p>16,000-year-old occupation predates possible land route.</jats:p>

<jats:p>New tools bring editing to synthetic biology.</jats:p>

<jats:p>Researchers reveal the 4-million-year-old face of the most ancient australopithecine.</jats:p>

<jats:p>Sampling in Hawaiian valley shows wider environment shapes each organism's microbial community.</jats:p>

<jats:p>The 2.2-billion-year-old Yarrabubba impact came at the end of a planetwide deep freeze.</jats:p>