Catálogo de publicaciones - revistas

<jats:title>Ciliary motors locked closed by Shulin</jats:title> <jats:p> Motile cilia and flagella are vital cellular organelles with functions that include setting up the left-right body axis, clearing airways of mucus, and driving single-cell movements. Cilia beating is powered by arrays of dynein motors, the key force generators being the outer dynein arm (ODA) complexes. Using the protozoan <jats:italic>Tetrahymena</jats:italic> , Mali <jats:italic>et al.</jats:italic> identified a factor, which they name Shulin, that binds newly synthesized ODAs. Cryo–electron microscopy revealed how Shulin locks the dynein motors together by shutting off motor activity and facilitating delivery of ODAs from the cytoplasm to their final position in the cilia. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article issue="6532" page="910" related-article-type="in-this-issue" vol="371">910</jats:related-article> </jats:p>

<jats:title>Vaccine prioritization</jats:title> <jats:p> There is likely to be high demand for the limited supplies of vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), so how should vaccine distribution be prioritized? Bubar <jats:italic>et al.</jats:italic> modeled across countries how uncertainty about a vaccine's characteristics affects prioritization strategies for reducing deaths and transmission (see the Perspective by Fitzpatrick and Galvani). In the model, vaccine efficacy and its ability to reduce disease and/or block transmission was accounted for in relation to age-related variations in susceptibility, fatality rates, and immune decline. In almost all circumstances, reducing fatalities required distributing the vaccine to those who are most at risk of death, usually persons over 60 years of age and those with comorbidities. If a vaccine is leaky or poorly efficacious in older adults, then priority could be given to younger age groups. To increase the available doses, further priority should be given to seronegative individuals. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6532" page="916" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abe6959">916</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6532" page="890" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abg2334">890</jats:related-article> </jats:p>

<jats:title>On the surface</jats:title> <jats:p> The uptake and hydrolysis of N <jats:sub>2</jats:sub> O <jats:sub>5</jats:sub> from the atmosphere by aqueous aerosols was long thought to occur by solvation and subsequent hydrolysis in the bulk of the aerosol. However, this mechanistic hypothesis was unverifiable because of the fast reaction kinetics. Galib <jats:italic>et al.</jats:italic> used molecular simulations to show instead that the mechanism is the inverse: Interfacial hydrolysis is followed by solvation into the interior. Their reactive uptake model is consistent with some existing experimental observations. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article issue="6532" page="921" related-article-type="in-this-issue" vol="371">921</jats:related-article> </jats:p>