Catálogo de publicaciones - revistas

<jats:title>Forming the early heart</jats:title> <jats:p> The heart is the first organ to form during development and is critical for the survival of the embryo. The precise molecular identities of the various cell types that make up the heart during these early stages remain poorly defined. Tyser <jats:italic>et al.</jats:italic> used a combination of transcriptomic, imaging, and genetic lineage–labeling approaches to profile the molecular identity and precise locations of cells involved in the formation of the mouse embryonic heart. This approach allowed them to identify the earliest known progenitor of the epicardium, the outermost layer of the heart, which is an important source of signals and cells during cardiac development and injury. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abb2986">eabb2986</jats:related-article> </jats:p>

<jats:title>Macrophages seal 'em in the coelom</jats:title> <jats:p> GATA6 <jats:sup>+</jats:sup> macrophages resident in body cavities exhibit both phagocytic and repair functions. However, the mechanisms by which these cells can identify and migrate to sites of injury have remained unclear. Using intravital imaging of mouse peritoneal cavities, Zindel <jats:italic>et al.</jats:italic> report that GATA6 <jats:sup>+</jats:sup> macrophages rapidly assemble clot-like structures in a process strongly analogous to thrombosis (see the Perspective by Herrick and Allen). The formation of these aggregates requires the expression of macrophage scavenger receptor domains and acts to plug wounds and promote healing. This pathway can be inadvertently activated during medical procedures, when macrophage aggregates can promote the generation of abdominal scar tissue known as adhesions. Inhibition of macrophage scavenger receptors may therefore be a useful therapeutic approach after surgeries that cause injury to body cavities. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abe0595">eabe0595</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6533" page="993" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abg5416">993</jats:related-article> </jats:p>

<jats:title>Some like it hot, others not</jats:title> <jats:p> Enzymes strike a delicate balance between features that enhance chemical reactivity and those that contribute to stable structure. Both features are important and can be unrelated or antagonistic. Pinney <jats:italic>et al.</jats:italic> combined rich experimental work on thermophilic and mesophilic variants of the enzyme ketosteroid isomerase (KSI) with bioinformatic data from a diverse set of bacterial enzymes to reveal the molecular determinants of thermal adaptation in enzymes. For KSI, they observed a trade-off between activity and thermal stability that comes down to a single active-site residue. With their larger dataset, they identified patterns of individual amino acid substitutions that are favored at higher temperatures, and also consider how networks of stabilizing interactions develop. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aay2784">eaay2784</jats:related-article> </jats:p>

<jats:title>Nature's “responsible” response to disease</jats:title> <jats:p> With the emergence of the COVID-19 pandemic, there have been global calls for the implementation of “social distancing” to control transmission. Throughout the world, some have resisted this requirement with the unfounded argument that it is unnecessary or ineffective. Social distancing, however, is a natural consequence of disease across animals, both human and nonhuman. Stockmaier <jats:italic>et al.</jats:italic> reviewed responses to disease across animal taxa and reveal how these responses naturally limit disease transmission. Understanding such natural responses and their impacts on pathogenic transmission provides epidemiological insight into our own responses to pandemic challenges. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abc8881">eabc8881</jats:related-article> </jats:p>

<jats:title>Sperm-specific natural selection</jats:title> <jats:p> Sperm cells are genetically haploid, but because of the cytoplasmic bridges that link cells, they can be transcriptionally diploid. However, some gene transcripts are not shared. Bhutani <jats:italic>et al.</jats:italic> sequenced single sperm from mice, cattle, and macaques to determine the extent of distortion in the expression of these putatively selfish transcripts, which the authors call genoinformative markers (GIMs). Investigating the evolutionary pressures on these GIMs, they found that they exhibited signatures of positive selection yet tend to be biased toward sperm function. This observation explains why, relative to other tissues, testis shows distinctive gene expression patterns. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abb1723">eabb1723</jats:related-article> </jats:p>