Catálogo de publicaciones - revistas

<jats:title>Hurting the virus by targeting the host</jats:title> <jats:p> Many host proteins play a role in the life cycle of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and some are required for viral replication and translation. There are efforts toward finding drugs that target viral proteins, but a complementary approach is to target these required host proteins. White <jats:italic>et al.</jats:italic> explored the antiviral activity of the cyclic depsipeptide drug plitidepsin, which targets the hosts cell's translational machinery (see the Perspective by Wong and Damania). The authors show that in cells, the drug is substantially more potent than remdesivir against SARS-CoV-2, with limited cellular toxicity. Prophylactic treatment protected mice against SARS-CoV-2 infection, so further investigation of plitidepsin as a therapeutic is warranted. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6532" page="926" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abf4058">926</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6532" page="884" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abg6837">884</jats:related-article> </jats:p>

<jats:title>Waiting for earthquakes to call</jats:title> <jats:p> Instrumenting the vast ocean floor is difficult and expensive but important for monitoring earthquakes and tsunamis. Zhan <jats:italic>et al.</jats:italic> used the polarization of regular telecommunication traffic to detect earthquakes and water swells in a 10,000-kilometer-long fiber-optic submarine cable (see the Perspective by Wilcock). The deep-water Curie cable is not as noisy as terrestrial counterparts, allowing the authors to detect strain from the cable. Results from the 9-month observation period showed how current submarine fiber-optic cables can also be used as a geophysical tool. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6532" page="931" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abe6648">931</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6532" page="882" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abg4479">882</jats:related-article> </jats:p>

<jats:title>Intriguing dynamics pattern in F + HD</jats:title> <jats:p> Despite decades of studies, the role of relativistic spin-orbit interactions in the dynamics of chemical reactions remains an intriguing topic. Using a high-resolution velocity map imaging crossed beams technique, Chen <jats:italic>et al.</jats:italic> observed an interesting pattern in the differential cross sections in the F + HD → HF + D reaction near the partial wave resonances (see the Perspective by Rakitzis). Further theoretical analysis showed that this pattern originates from quantum interference between spin-orbit split partial wave resonances with different total parities. The effect of the fine structure of the partial waves observed for this long known yet not completely explored three-atom system represents one more remarkable demonstration of the truly quantum nature of chemical reaction dynamics. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6532" page="936" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abf4205">936</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6532" page="886" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abg3184">886</jats:related-article> </jats:p>

<jats:title>Not enough room</jats:title> <jats:p> Modern carnivore communities include species that span a range of body sizes. For example, on the African savannah, there are small species (mongooses), medium species (wild dogs), and large species (lions). This variation reflects available prey sources that best suit each group. Carnivorous dinosaur communities, however, were missing species that fall into the middle, or mesocarnivore, group as adults. Schroeder <jats:italic>et al.</jats:italic> looked across communities, space, and time and found that this absence appears to have been driven by the distinctive biology of dinosaurs, in which giant adults start out as tiny hatchlings. Growing juvenile dinosaurs thus filled the other niches and limited trophic species diversity. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6532" page="941" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abd9220">941</jats:related-article> </jats:p>

<jats:title>The origin of r-process elements</jats:title> <jats:p> Theoretical models predict that the synthesis of heavy elements by the rapid neutron capture process (r-process) occurs in extreme astrophysical environments such as neutron star mergers or some types of supernovae. Testing those predictions by comparing them with the isotopic record has been difficult. Côté <jats:italic>et al.</jats:italic> examined two r-process isotopes, iodine-129 and curium-247, both of which have half-lives of 15.6 million years. Therefore, their ratio remains constant even long after the nucleosynthesis event. The ratio of those isotopes at the time of Solar System formation is recorded in meteorites. Comparing this value with nuclear astrophysics calculations shows that the most likely source was moderately neutron-rich material ejected from a binary neutron star merger. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article issue="6532" page="945" related-article-type="in-this-issue" vol="371">945</jats:related-article> </jats:p>

<jats:title>Laser-based generation of random numbers</jats:title> <jats:p> The security of our digital networks is underpinned by the ability to generate streams of random numbers or bits. As networks expand in an ever-connected way, the challenge is to increase the generation rate of the random numbers to keep pace with demand. Kim <jats:italic>et al.</jats:italic> designed a chip-scale laser diode that generates random bits at an ultrahigh rate (see the Perspective by Fischer and Gauthier). By tailoring the geometry of the cavity, they were able to exploit the spatiotemporal interference of many lasing modes to generate picosecond-scale emission intensity fluctuations in space and time, producing ultrafast random bit streams in parallel. Such a device will find a wide range of applications requiring an ultrafast, compact, robust, and energy-efficient random bit generator. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6532" page="948" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abc2666">948</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6532" page="889" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abg5445">889</jats:related-article> </jats:p>